Prognostic value of M2 macrophage-related genes and their importance in the immunotherapy response in hepatocellular carcinoma.

ABSTRACT: Liver hepatocellular carcinoma (LIHC) is a major contributor to cancer-associated mortality worldwide, with a poor prognosis due to late-stage diagnosis and limited therapeutic options. M2 macrophages serve crucial roles in the tumor microenvironment (TME), contributing to tumor progression, immune evasion and resistance to therapy. However, the prognostic importance of M2 macrophage-related genes in LIHC and their potential for predicting responses to immunotherapy remain underexplored. A bioinformatics analysis was performed using The Cancer Genome Atlas data to identify M2 macrophage-related genes in LIHC. Differential expression and weighted gene co-expression network analysis were used to identify key gene modules and a prognostic model was developed and validated using Kaplan-Meier a

SUBMITTER: Wang A 

PROVIDER: S-EPMC12489720 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature