Exploring Caffeine Extraction Using Hydrophobic Deep Eutectic Solvents: Experimental and Theoretical Approaches.

ABSTRACT: Hydrophobic deep eutectic solvents (HDESs) are emerging as sustainable, biodegradable, and nontoxic alternatives to traditional organic solvents in liquid-liquid extraction processes. This study investigates the use of HDESs, specifically eutectic mixtures of dl-menthol combined with acetic or hexanoic acids, for extracting caffeine from coffee beans (CB), coffee skin (CS), and guaraná drink (GD). Solvent screening using COSMO-RS modeling was performed to identify effective HDES systems. Caffeine detection employed UV/vis spectrophotometry at 274 nm (dl-menthol/acetic acid system) and 284 nm (dl-menthol/hexanoic acid system), with application of Gaussian fitting to minimize spectral interferences. The optimal extraction conditions were determined to be 65 °C and a 1:1 initial solution to s

SUBMITTER: Pishro KA 

PROVIDER: S-EPMC12489721 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature