Cardiometabolic and anxiogenic consequences of chronic social defeat stress in male mice.

ABSTRACT: Social adversity, such as that which occurs during subjugation to a lower social status, has profound psychological and cardiometabolic consequences that are conserved across species. Clinically, such adversity often arises from being of a lower socioeconomic status and may contribute to health disparities in cardiometabolic and affective disorders. To develop a better understanding of the cardiometabolic consequences of social adversity, we employ chronic social defeat stress (CSDS) in adult male mice. CSDS results in increases in body mass, that are accompanied by elevated lean and fluid mass, as well as several somatic indices of chronic stress. Moreover, mice exposed to CSDS exhibit increased anxiety-like behavior, spending more time in the closed arms of the elevated plus maze and les

SUBMITTER: Scott KA 

PROVIDER: S-EPMC12489766 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature