Interactive effects of early life adversity and adolescent basolateral amygdala activity on corticolimbic connectivity and behavior.

ABSTRACT: Corticolimbic development is shaped by the environment and relies on coordinated neuronal activity. Prior work revealed that early life adversity (ELA) leads to hyperinnervation of basolateral amygdala (BLA) projections to the prefrontal cortex (PFC) beginning in early adolescence. Both ELA and corticolimbic hyperconnectivity are associated with anxiety-like behavior, however the underlying developmental processes driving these effects are largely unknown. Here we investigated interactive impacts of rearing environment and neuronal activity on behavior and corticolimbic connectivity in rats. We first found that BLA-PFC hyperinnervation was associated with enhanced BLA-evoked PFC local field potentials in adolescents exposed to maternal separation (MS) ELA. Since ELA reportedly increases ac

SUBMITTER: Cody CR 

PROVIDER: S-EPMC12489772 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature