Pre-CBT resting-state connectivity and white matter integrity in OCD remission: A multimodal MRI study.

ABSTRACT:

Background

Obsessive-compulsive disorder (OCD) is commonly treated with cognitive-behavioral therapy (CBT), yet many patients fail to achieve remission. Neuroimaging markers, such as pre-treatment functional and structural connectivity, may help elucidate OCD pathology and CBT mechanisms, and predict treatment outcomes. This study investigates the relationship between pre-treatment functional and structural connectivity and remission status in OCD patients following CBT.

Methods

Thirty-three OCD patients underwent multimodal MRI, including resting-state fMRI to assess pre-treatment functional connectivity and diffusion tensor imaging (DTI) to evaluate white matter integrity. Functional connectivity multivariate pattern analysis (fc-MVPA) identified patterns linked to treatme

SUBMITTER: Ikemizu Y 

PROVIDER: S-EPMC12489777 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature