Electron donor-acceptor complex offers a diverse approach for carbonyl alkylative amination.

ABSTRACT: The synthesis of α-tertiary amino acids and amines is crucial in biochemistry and medicinal chemistry. However, creating tertiary carbon centers has traditionally been challenging due to the lack of effective, sustainable, and straightforward mild protocols. This current work presents a method for creating α-tertiary carbon centers that leverages the formation of an electron donor-acceptor (EDA) complex, where electron-poor imines act as the acceptor and electron-rich 1,4-dihydropyridine serves as the donor. This interaction facilitates the generation of α-amino radicals through a charge transfer phenomenon. In the presence of a suitable radical trapping reagent, these α-amino radicals can forge C-C bonds, where H-DHP acts solely as a reductant. Additionally, a radical cross-coupling proce

SUBMITTER: Paul H 

PROVIDER: S-EPMC12489803 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature