Prospective associations of obesity heterogeneity, serum proteins, and carotid atherosclerosis risk.

ABSTRACT:

Background

Obese individuals exhibit considerable heterogeneity in developing cardiovascular diseases, yet the underlying molecular mechanisms remain unclear. We aimed to investigate the prospective associations between obesity phenotypes, serum proteomics, and carotid atherosclerosis (CAS) incidence.

Methods

This cohort study included 3162 participants from the Guangzhou Nutrition and Health Study, with 413 proteins profiled from 6803 serum samples collected at three time-points. Obesity phenotypes included metabolically healthy non-obesity (MHNO) and metabolically healthy/unhealthy obesity (MHO/MUO).

Findings

We identified 11 proteins influenced by MUO (vs. MHO) over time, with their combined score positively associated with incident CAS (HR: 1.16; 95% CI: 1.01-1.34

SUBMITTER: Zhong H 

PROVIDER: S-EPMC12489834 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature