Anionic Boron-Cluster BODIPY Conjugates As Promising Photosensitizers for Targeted Antimicrobial Photodynamic Therapy.

ABSTRACT: We report the design, synthesis, photophysical characterization, and antimicrobial evaluation of three novel anionic boron-cluster-BODIPY conjugates, BDP-FES (BODIPY-ferrabisdicarbollide), BDP-COS (BODIPY-cobaltabisdicarbollide), and BDP-B ₁₂ (BODIPY-closo-dodecaborate), as photosensitizers for antimicrobial photodynamic therapy (aPDT). Covalent attachment of anionic boron clusters to the iodinated BODIPY scaffold was confirmed by multinuclear NMR spectroscopy and resulted in red-shifted absorption (λ_abs,max = 545 nm) and emission (λ_f,max = 600-611 nm) maxima, along with pronounced suppression of fluorescence quantum yields due to heavy-atom-promoted triplet state generation. While singlet oxygen generation decreased compa

SUBMITTER: Ordonez-Hernandez J 

PROVIDER: S-EPMC12489852 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature