Novel Role of Copper Transporter CTR1 and Therapeutic Potential of Copper Chelators in Retinal Ischemia-Reperfusion Injury.

ABSTRACT:

Purpose

Retinal ischemia contributes to vision loss in ischemic and diabetic retinopathies through oxidative stress, neurovascular injury, and inflammation. Copper (Cu), whereas an essential micronutrient, can be toxic in excess and is regulated by Cu transporters such as CTR1. However, the role of CTR1 in ischemic retinopathy remains unclear.

Methods and results

Retinal ischemia-reperfusion (IR) injury was induced by elevating intraocular pressure (IOP) to 110 millimeters of mercury (mm Hg) for 40 minutes in the right eyes of Ctr1 heterozygous (Ctr1+/-) and wild-type (WT) mice. In WT mice, IR triggered rapid CTR1 upregulation and increased retinal Cu levels (measured by inductively coupled plasma mass spectrometry [ICP-MS]). IR injury caused retinal ganglion cell (RGC) loss

SUBMITTER: Yamamoto M 

PROVIDER: S-EPMC12489862 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature