Efficient and Wide Chemical-Space Ionization of Organic Contaminants Using LC-MS with a Miniaturized Plasma Source Applying Different Discharge Gases.

ABSTRACT: Dielectric barrier discharge ionization has gained significant interest due to its versatility and broad chemical coverage. Although electrospray ionization (ESI) is the most commonly used ionization source for organic contaminant analysis by liquid chromatography-mass spectrometry (LC-MS), it has limitations such as low ionization efficiency for nonpolar compounds and matrix effects. This study investigates the potential of flexible microtube plasma (FμTP) as an alternative ionization source for the LC-MS determination of multiclass pesticides comprising ESI-amenable and organochlorine contaminants. The analytical performance of FμTP was assessed in terms of limits of quantification, reproducibility, linearity, and matrix effects, comparing the results to those obtained with ESI and atmos

SUBMITTER: Cano-Carrillo I 

PROVIDER: S-EPMC12489893 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature