Transduction Mechanisms for Cold Temperature in Mouse Trigeminal and Vagal Ganglion Neurons Innervating Different Peripheral Organs.

ABSTRACT:

Aim

To elucidate the molecular mechanism of cold sensing by visceral sensory endings, a side-by-side characterization of cold-sensitive (CS) neurons in adult mouse trigeminal (TG) and vagal ganglia (VG) was performed.

Methods

A combination of physiological, pharmacological, molecular, and genetic tools was employed on trigeminal and vagal neurons.

Results

CS neurons are more abundant in VG, and the majority co-express TRPA1. Cold-evoked responses are severely blunted in Trpa1 KO mice. In contrast, TRPM8 deletion or pharmacological TRPM8 blockade had little impact on VG cold sensitivity. In Trpm8^eYFP reporter mice, VG TRPM8 expression was restricted to the rostral jugular ganglion. In vivo labeling of airway-innervating VG neurons demonstrated their enhanced

SUBMITTER: Gers-Barlag K 

PROVIDER: S-EPMC12489895 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature