Changes in the olfactory tract of patients with early Parkinson's disease: A DTI tractography study.

ABSTRACT:

Introduction

olfactory impairment is a clinical feature of Parkinson's disease (PD) even in the early phases. Diffusion tensor imaging fiber tracking analysis (DTI-FTA) has been able to highlight changes in the olfactory tract in PD, however in early phases of PD this analysis has not been investigated. We investigated the olfactory tract by DTI-FTA in early stages of PD (ePD).

Methods

All patients were assessed using the Italian Olfactory Identification Test (IOIT), the Movement Disorder Society-Unified Parkinson's Disease Rating Scale-Part III (MDS-UPDRS-III) and the Hoehn and Yahr (H&Y) scale. Diffusion imaging was conducted by 3 T MRI.

Results

Overall, 26 PD patients and 20 healthy subject were recruited. Hyposmia was observed in all PD patients. DTI-FTA of the ol

SUBMITTER: Nigro P 

PROVIDER: S-EPMC12489904 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature