Global burden of Alzheimer's disease and other dementias (1990-2021): inequality, frontier, and decomposition analysis.

ABSTRACT:

Introduction

Alzheimer's disease and other dementias (ADOD) represent a growing global health crisis driven by the rapid aging of the population. Using data from the 2021 Global Burden of Disease (GBD) study, we provide updated global and national estimates of the ADOD burden from 1990 to 2021, quantify key risk factors, and offer evidence to guide resource allocation and prevention strategies.

Methods

We analyzed age-standardized incidence, prevalence, mortality, and disability-adjusted life years (DALYs) rates, along with the burden attributable to ADOD-related risk factors. Health disparities were assessed using the slope index of inequality and concentration index. We used frontier analysis to evaluate outcomes relative to development levels. Decomposition analysis ident

SUBMITTER: Fu H 

PROVIDER: S-EPMC12489941 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature