Burden and trends of major depressive disorders among women of childbearing age and the impact of the COVID-19 pandemic: insights from the global burden of disease study 2021.

ABSTRACT:

Background

Major depressive disorder (MDD) exhibits a pronounced female predominance, contributing substantially to disability-adjusted life-years (DALYs) among women of childbearing age (WCBA; 15-49 years). The COVID-19 pandemic intensified this burden via psychosocial stressors and disrupted healthcare access, yet integrated analyses of pre- and post-pandemic trends are scarce.

Methods

Leveraging GBD 2021 data, we assessed MDD prevalence, incidence, and DALYs among WCBA globally, regionally, and nationally (1990-2021). Burden estimates were reported as point values with 95% uncertainty intervals (UIs). Temporal trends were quantified via estimated annual percentage change (EAPC) and absolute percentage change (PC). We employed autoregressive integrated moving average (ARIM

SUBMITTER: Liao G 

PROVIDER: S-EPMC12489947 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature