Intermittent fasting triggers interorgan communication to improve the progression of diabetic osteoporosis.

ABSTRACT: Diabetic osteoporosis is a disease that seriously affects health, and intermittent fasting is a promising dietary approach to manage diabetes. The objective of our study was to analyze the effects of intermittent fasting on diabetic osteoporosis and its possible mechanisms. Streptozotocin-induced diabetes in mice was treated by intermittent fasting. Micro-CT and Immunostaining techniques were utilized to evaluate glycogen synthesis and morphological changes in the tibia. Gut microbiota analysis involved 16S rRNA gene amplification and sequencing. Liquid chromatography-mass spectrometry was employed, and quantitative real-time PCR assessed gene expression levels. Our study found that intermittent fasting improved blood glucose levels in diabetic mice and simultaneously enhanced cancellous b

SUBMITTER: Guan Z 

PROVIDER: S-EPMC12490001 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature