Global burden of MDR-TB and XDR-TB: trends, inequities, and future implications for public health planning.

ABSTRACT:

Background

Drug-resistant tuberculosis (TB) remains a major global health threat, reflecting disparities in healthcare capacity, access, and socioeconomic development. Previous research often lacks geographic breadth. This study provides a comprehensive assessment of the global, regional, and national burden of Multidrug-resistant TB without extensive drug resistance (MDR-TB) and extensively drug-resistant TB(XDR-TB) from in Global Burden of Disease Study (GBD) 2021 Study 1990 to 2021, with a focus on distributional inequities. The findings aim to guide resource prioritization, inform targeted interventions, and reduce the burden in high-risk populations.

Methods

We systematically assessed the global, regional, and national burden of MDR-TB and XDR-TB, along with their chang

SUBMITTER: Tan EL 

PROVIDER: S-EPMC12490063 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature