Detection of AcrAB efflux pump mediated ciprofloxacin resistance in Escherichia coli and Klebsiella pneumoniae in Nepal.

ABSTRACT:

Background

Antimicrobial resistance (AMR) has emerged as a serious public health threat with a sharply increasing burden globally. Resource limited countries like Nepal are facing difficulties in the fight against AMR. This has been further worsened due to the lack of adequate molecular data. Ciprofloxacin resistance by AcrAB-TolC efflux pump (EP) genes in Gram-negative bacteria becomes a challenging issue due to its potential role in multidrug resistance (MDR). This hospital-based cross-sectional study investigated these genes in ciprofloxacin-resistant Escherichia coli and Klebsiella pneumoniae isolates from patients attending a tertiary care hospital in Kathmandu, Nepal. Different clinical specimens (n = 877) were subjected to bacterial isolation and identification. Antibiotic s

SUBMITTER: Kharel S 

PROVIDER: S-EPMC12490087 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature