Clinical implementation of intensity modulated proton therapy for testicular seminoma.

ABSTRACT:

Background and purpose

We have previously shown that proton therapy results in considerable reduced doses to abdominal organs at risk (OAR) which likely reduces the patient's risk of a second malignant tumor, which is vital for this young population with favourable prognosis. Here, we present dosimetric results after implementing intensity modulated proton therapy (IMPT) as a national standard for seminoma. Patient/material and methods: Thirty patients with stage IIA and IIB (< 3 cm) seminoma were treated with five-field robustly multi-field optimised (MFO) proton therapy to 20-24 Gy (relative biological effectiveness [RBE]) to the dog-leg retroperitoneal volume followed by a boost of 10-16 Gy (RBE) to the nodal metastasis. Control CTs were performed routinely, and target coverage

SUBMITTER: Ronde HS 

PROVIDER: S-EPMC12490103 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature