Early cognitive decline in amyotrophic lateral sclerosis and its relation to driving: an observational study.

ABSTRACT:

Objective

To determine whether early cognitive function in amyotrophic lateral sclerosis patients predicts future cognitive function and the decision to cease driving.

Design

Observational study.

Subjects

Patients with amyotrophic lateral sclerosis.

Methods

Subjects underwent baseline assessments of cognitive function and driving ability within 4 months of diagnosis, with follow-up evaluation conducted 4 months thereafter. Two hypotheses were tested: (H1) cognitive status remains stable between baseline and follow-up, (H2) patients with baseline cognitive impairment cease driving earlier than those without cognitive changes. Data were analysed using t-tests and regression analysis, with visual inspection of the results.

Results

Of 31 subjects tested at b

SUBMITTER: Taule T 

PROVIDER: S-EPMC12490105 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature