Excessive cholesterol accelerates intervertebral disc degeneration by promoting the polarization of M1 macrophages.

ABSTRACT:

Background

Intervertebral disc degeneration (IVDD) is the primary cause of low back pain (LBP). Dyslipidaemia can induce a chronic inflammatory state in the body, promote the polarization of macrophages, and may affect the homeostasis of the intervertebral disc (IVD). However, the relationship between dyslipidaemia and IVDD remains unclear.

Methods

This study encompassed human subjects and animal models. Techniques used: cell counting kit-8 (CCK8), western blotting, immunofluorescence staining, immunohistochemical staining, flow cytometry, enzyme-linked immunosorbent assay (ELISA), reverse transcription-quantitative polymerase chain reaction (RT-qPCR), and statistical analysis.

Results

Through a retrospective analysis involving 196 patients, this study found that high

SUBMITTER: Chang SJ 

PROVIDER: S-EPMC12490159 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature