Association of progesterone receptor status with breast cancer prognosis: a meta-analysis.

ABSTRACT:

Background

Breast cancer (BC) prognosis is influenced by hormones, of which progesterone receptor (PR) status is controversial for BC prognosis, possibly related to clinical characteristics.

Objective

This study was to determine the impact of PR status on BC prognosis and explore the differences across patient subgroups.

Methods

PubMed, Cochrane Library, Embase, and Web of Science were searched for relevant studies until July 2024. NOS (Newcastle-Ottawa Scale) was leveraged for quality appraisal. Meta-analysis was performed using STATA15.1.

Results

Thirty-five studies were included, involving 89,164 patients. PR-negative status was associated with worse overall survival compared to PR-positive status (HR 1.70, 95%CI 1.42 to 2.04; p < 0.001). Similar results wer

SUBMITTER: Hou Y 

PROVIDER: S-EPMC12490167 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature