Supramolecular Assembly and Interfacial Hydration of Tandem Repeat Dipeptides on 2D Nanomaterials: Insights From 3D-AFM Measurements and MD Simulations.

ABSTRACT: The design of functional bionanomaterials formed by peptide supramolecular organizations on atomically-thick solids relies on understanding molecular self-assembly mechanisms. This study investigates the structural aspects of short peptide assemblies on 2D crystallographic solid surfaces, aiming to create structurally well-defined peptide-solid hybrid systems with soft interfaces. The understanding of complex interplay between sequence-specific molecular interactions among peptides and substrates toward controlled nanoarchitecture formation remains challenging. The lack of understanding of the role of local hydration structures at the molecular level further hinders the rational design and functional control of these systems. A custom-built atomic force microscope, complemented by molecula

SUBMITTER: Yurtsever A 

PROVIDER: S-EPMC12490188 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature