Synergistic Effect of Prolonged Oxygenation and Reactive Oxygen Species Scavenging on Diabetic Wound Healing Using an Injectable Thermoresponsive Hydrogel.

ABSTRACT: Diabetic wounds have complex environments, which leads to persistent inflammation caused by high level of reactive oxygen species (ROS), resulting in impeded angiogenesis and causing chronic hypoxia. Recent studies have shown that continuous oxygen supply, along with ROS reduction, can accelerate the healing process of diabetic wounds. However, the initial burst release of oxygen and poor stability of ROS scavengers have diminished therapeutic effectiveness. Moreover, a significant gap exists in research on the long-term synergistic effects of oxygenation and ROS scavenging. Herein, an injectable, thermoresponsive, oxygen-releasing, and ROS-scavenging hydrogel (ORH) system is developed based on calcium peroxide-loaded gelatin microspheres (OGMs) and chitosan-catalase complexes (CSCATs), wh

SUBMITTER: Lee J 

PROVIDER: S-EPMC12490195 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature