Transdiagnostic pathways from early social stress to psychopathology: a 20-year prospective study.

ABSTRACT:

Background

Adverse family environments confer susceptibility to virtually all psychiatric problems. This study evaluated two possible models to explain this diversity of associations. Stressful family circumstances during childhood could either activate general, transdiagnostic liabilities to mental disorder or promote numerous disorder-specific liabilities.

Methods

We recruited a high-risk sample of 815 mother-offspring pairs and assessed social stressors in the family context prospectively from the perinatal period through offspring age 5. We factor analyzed offspring mental disorder diagnoses at age 20 to parse transdiagnostic and disorder-specific dimensions of psychopathology.

Results

Structural analyses revealed nearly equivalent prospective effects of early fam

SUBMITTER: Conway CC 

PROVIDER: S-EPMC12490286 | biostudies-literature | 2018 Aug

REPOSITORIES: biostudies-literature