Psychological distress in older adults: associations with epigenetic markers of ageing, inflammation, and depression, and joint effects on mortality.

ABSTRACT:

Background

Psychological distress is associated with adverse health outcomes. We aimed to assess whether the health impacts of psychological distress could be captured by epigenetic markers of ageing, inflammation, and depression, and whether these markers and psychological distress have a synergistic association with mortality in older Australians.

Methods

Blood DNA methylation data for 1146 participants (31 % females, mean age: 69 years) in the Melbourne Collaborative Cohort Study were used to calculate epigenetic markers of ageing (PCPhenoAge, PCGrimAge, bAge, DunedinPACE) and inflammation (C-reactive protein [mCRP]), and two methylation scores for depression. Psychological distress was assessed by the Kessler scale (K10). Linear regress

SUBMITTER: Li DL 

PROVIDER: S-EPMC12490524 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature