Metabolic syndrome and the risk of incident heart failure: a prospective cohort study.

ABSTRACT:

Aim

Previous studies have reported the link between metabolic syndrome (MetS) and multiple cardiovascular diseases. This study aimed to comprehensively investigate the role of MetS in the risk of developing HF.

Methods

This is a prospective cohort study based on UK Biobank. The components of MetS included increased blood pressure (P), central obesity (W), elevated blood glucose (G), reduced HDL cholesterol (H) and increased triglycerides (T); the cumulative burden of MetS components was defined as the sum of the presence of altered MetS components; and specific clusters of MetS components was defined as different combinations of the altered components. The outcome was incident heart failure. Cox proportional-hazards models were used to generate the estimates.

Results

SUBMITTER: Wei H 

PROVIDER: S-EPMC12490533 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature