Inflammation, childhood trauma, and symptom dimensions in schizophrenia: a path-analysis study.

ABSTRACT:

Introduction

It has been postulated that immune dysregulations may establish a link between early risk factors, such as childhood trauma (CT), and the later development of schizophrenia. Schizophrenia and experience of childhood trauma (CT) have independently been associated with increased circulating levels of inflammatory biomarkers, while CT and inflammation have also been linked to particular clinical features of the disorder. We investigated whether increased levels of inflammatory biomarkers were underpinned by CT among subjects with schizophrenia, and whether this inflammation mediated the relationship between CT and symptom dimensions.

Methods

451 subjects from the FACE-SZ ("FondaMental Academic Centres of Expertise for Schizophrenia") cohort were included. Path-anal

SUBMITTER: Silva F 

PROVIDER: S-EPMC12490581 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature