LncRNA PELATON regulates Th2 cell differentiation by miR-10b-5p/GATA3 axis in allergic rhinitis.

ABSTRACT:

Background

Long non-coding RNAs (lncRNAs) have been increasingly recognized as critical regulators in the pathogenesis of immunoinflammatory diseases. Nevertheless, their mechanistic contributions to Th2-driven allergic rhinitis (AR) remain unclear. This study investigated the immunomodulatory function of lncRNA PELATON in AR pathogenesis by exploring its regulatory effects on Th2 cell differentiation.

Methods

A total of 32 participants were enrolled, comprising 16 patients diagnosed with AR and 16 control subjects. The allergy levels of the participants were assessed using the skin prick test (SPT), and the levels of PELATON expression in PBMCs were detected by qPCR. Spearman's correlation analysis was used to calculate the correlation between the 2 variables. Changes in GA

SUBMITTER: Liu Z 

PROVIDER: S-EPMC12490600 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature