Understanding the global rise of artemisinin resistance: Insights from over 100,000 <i>Plasmodium falciparum</i> samples.

ABSTRACT: Artemisinin partial resistance (ART-R) in Plasmodium falciparum is a major challenge to malaria control globally. Over the last two decades, ART-R has spread widely across Southeast Asia, undermining public health strategies and hindering elimination. As of 2024, ART-R has now emerged in East Africa, with the potential to dramatically impact current efforts to control malaria in the region. Mitigating its spread requires detailed genomic surveillance of point mutations in the kelch13 gene, the primary known determinant of artemisinin resistance. Although extensive surveillance data on these markers is available, it is distributed across many literature studies and open databases. In this review, we aggregate spatiotemporal data for 112,933 P. falciparum samples collect

SUBMITTER: Balmer AJ 

PROVIDER: S-EPMC12490857 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature