Endophilin A1 facilitates organization of the GABAergic postsynaptic machinery to maintain excitation-inhibition balance.

ABSTRACT: The assembly and operation of neural circuits in the brain rely on the coordination and balance of excitatory and inhibitory activities. Inhibitory synapses are key regulators of the functional balance of neural circuits. However, due to the diversity of inhibitory presynaptic neurons, the complex composition of postsynaptic receptor subunits, and the lack of typical postsynaptic dense structure, there are relatively few studies on the regulatory mechanisms for inhibitory synaptic structure and function, and insufficient understanding of the cellular and molecular abnormalities of inhibitory synapses in neurological and neuropsychiatric disorders. Here, we report a crucial role for endophilin A1 in inhibitory synapses. We show that endophilin A1 directly interacts with the inhibitory posts

SUBMITTER: Chen X 

PROVIDER: S-EPMC12490859 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature