The bidirectional interplay between RNA processing and mechanotransduction.

ABSTRACT: Through mechanotransduction, cells sense and respond to mechanical stimuli from their environment. A mechanical stimulus is first detected by a mechanosensor, then converted into a biochemical signal, which can ultimately control the expression of genes. RNA processing, which includes canonical and alternative splicing, 3' end polyadenylation, and 5' end capping, is a mechanism that fine-tunes gene expression regulation. Here, we provide an overview of recent studies revealing substantial links between mechanotransduction and RNA processing, with a focus on alternative splicing and polyadenylation. We first describe the molecular players that are known to mediate mechanotransduction. Then, we examine how mechanical forces inform the functions of RNA-binding proteins. We next summarize rece

SUBMITTER: Bais GB 

PROVIDER: S-EPMC12490864 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature