Differential Anxiety-Depression-CRP Network Structures Across Insomnia Severity Levels: Evidence From UK Biobank.

ABSTRACT: Background: This study investigated the relationships between anxiety, depression symptoms, and C-reactive protein (CRP) across insomnia severity levels using network analysis and examined the structural differences within these networks. Methods: Gaussian graphical model network analysis with Least Absolute Shrinkage and Selection Operator (LASSO) regularization was conducted on UK Biobank data (N = 143,027). Depression and anxiety symptoms were assessed using the 9-item Patient Health Questionnaire (PHQ-9) and 7-item Generalized Anxiety Disorder Scale (GAD-7), respectively. CRP was quantified using immunoturbidimetric-high-sensitivity analysis. Participants were categorized by insomnia frequency (never/rarely, sometimes, and usually). The strength symptoms and expect

SUBMITTER: Luo X 

PROVIDER: S-EPMC12490932 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature