Circulating vitamin D concentrations and the risk of urticaria: A bidirectional two-sample Mendelian randomization study.

ABSTRACT:

Background and objectives

Vitamin D deficiency has been linked to urticaria, but causality remains uncer-tain. We used Mendelian randomization (MR) to investigate potential causal effects of vitamin D and its me-tabolites on urticaria risk.

Methods and study design

Summary statistics from genome-wide association studies (GWAS) of total 25-hydroxyvitamin D [25(OH)D] (n=120,618), 25-hydroxyvitamin D3 [25(OH)D3] (n=40,562), and C3-epimer-25-hydroxyvitamin D3 [C3-epi-25(OH)D3] (n=40,562) in Europeans were used, along with data on urticaria and its subtypes from FinnGen consortium (R10 release). For validation, we performed additional MR analyses using a larger dataset that meta-analyzed data from the UK Biobank and GWAS results from the SUNLIGHT consortium (n=496,946) as exposur

SUBMITTER: Chai HX 

PROVIDER: S-EPMC12490950 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature