Prognostic significance and potential association between ALDOA and ENO1 in gastric cancer.

ABSTRACT: Background: Gastric cancer (GC) is one of the most common malignant tumors and a leading cause of cancer-related death worldwide. Although advances in surgical techniques and novel treatment techniques such as immunotherapy have improved the prognosis of many tumors, the effectiveness of treatment for advanced GC patients is still limited. Methods: Immunohistochemistry (IHC) staining analysis was conducted to compare the expression of ALDOA and ENO1 in GC tissues and adjacent normal tissues, complemented by bioinformatics analysis using GEPIA, LinkedOmics, and TIMER databases to explore their association with glycolysis and immune cell infiltration. A survival prediction nomogram was constructed based on Cox proportional hazard model data to evaluate prognostic significance.

SUBMITTER: Wang X 

PROVIDER: S-EPMC12490978 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature