Impact of euploid blastocyst developmental stage and morphological grading on pregnancy outcomes in young recurrent pregnancy loss patients: association with parental chromosomal status.

ABSTRACT:

Objective

This study investigated the impact of blastocyst developmental stage and morphological grading on pregnancy outcomes following single euploid frozen-thawed blastocyst transfer (SE-FBT) in young patients with recurrent pregnancy loss (RPL) and balanced chromosomal translocations (BCTs), compared to patients with normal karyotypes.

Methods

A retrospective cohort analysis was performed on 449 SE-FBT cycles (2017-2023), comprising 177 cycles from patients with BCT and 272 cycles from patients with normal karyotypes. Blastocysts were categorized according to their developmental stage (day 5 [D5] versus day 6 [D6]) and morphological grading (good versus poor). Multivariable logistic regression models were used to adjust for potential confounders.

Results

Among BCT

SUBMITTER: Zhang R 

PROVIDER: S-EPMC12490980 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature