Deciphering the shared genetic structure between hip osteoarthritis and femoral neck bone mineral density.

ABSTRACT:

Background

While the association between hip osteoarthritis (HOA) and femoral neck bone mineral density (FN-BMD) is established, their shared genetic architecture remains elusive. This study aims to explore the genetic correlation and underlying mechanisms.

Methods

The present study applied bidirectional Mendelian randomisation (MR) to investigate causal relationships between HOA and FN-BMD. The quantification of genetic correlations was achieved by employing linkage disequilibrium score regression (LDSC) and high-definition likelihood (HDL) inference. Multi-trait analysis of genome-wide association studies (MTAG) have been shown to enhance statistical resolution, thereby unveiling hitherto unreported genetic associations. Independent MTAG-HOA risk loci were identified throu

SUBMITTER: Zhou J 

PROVIDER: S-EPMC12491044 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature