PSMA PET/CT in biochemical recurrence of prostate cancer with PSA levels ≤ 0.2 ng/mL: a German multicenter analysis of conventional PSMA tracers, including [⁶⁸Ga]Ga-PSMA-11, [⁶⁸Ga]Ga-PSMA I&T, and [¹⁸F]PSMA-1007.

ABSTRACT:

Background

Prostate-specific membrane antigen (PSMA)-directed positron emission tomography/computed tomography (PET/CT) has emerged as a highly accurate imaging modality for detecting tumor lesions in patients with biochemical recurrence (BCR) of prostate cancer (PC). While detection rates of lesions suspicious for PC relapse are known to increase with rising prostate-specific antigen (PSA) levels, data on the efficacy of PSMA PET/CT at very low PSA values (≤ 0.2 ng/mL) remain limited.

Methods

In this multicenter study, we analyzed 321 patients with BCR and a PSA value ≤ 0.2 ng/mL across five German academic centers, using three different PSMA-targeted radiotracers: [⁶⁸Ga]Ga-PSMA-11, [⁶⁸Ga]Ga-PSMA I&T, and [¹⁸F]PSMA-1007 and analyzed the dete

SUBMITTER: Burgard C 

PROVIDER: S-EPMC12491085 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature