Accepting to Participate in an Early-Phase Clinical Trial in Oncology: A Qualitative Study on the Patients' Experiences, Understanding, and Inner Motivations.

ABSTRACT:

Background

The clinical trial landscape in oncology has evolved, with shifting endpoints and increased emphasis on early-phase clinical trials (EPCTs) across European centers.

Aims

This study aimed to update knowledge on the experiences of patients enrolling in EPCTs, focusing on the individual/contextual factors influencing decision-making, and how to improve ethical and psycho-oncological support.

Methods

This qualitative single-center study was part of a broader multicenter project. Twenty-five patients with locally advanced or metastatic solid cancer, for whom standard therapies had failed, were interviewed face-to-face, at a French EPCT center. A reflexive thematic analysis of the transcripts was conducted, following Braun and Clarke's six-step approach.

Resul

SUBMITTER: Guerdoux E 

PROVIDER: S-EPMC12491123 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature