Regulation of tau protein by circCwc27: shared pathogenic mechanisms in type 2 diabetes mellitus and Alzheimer's disease.

ABSTRACT:

Background

Alzheimer's disease (AD) and type 2 diabetes mellitus (T2DM) are distinct yet interconnected disorders that frequently co-occur. While insulin resistance and impaired glucose metabolism have been implicated in their shared pathogenesis, the molecular mechanisms underlying this comorbidity remain incompletely understood. Emerging evidence suggests that circular RNAs (circRNAs), particularly those enriched in neural and metabolic tissues, may play regulatory roles in both diseases.

Methods

We conducted integrated transcriptomic analyses using Gene Expression Omnibus (GEO) datasets to identify differentially expressed genes in AD and T2DM. Protein-protein interaction (PPI) network construction and enrichment analyses identified common hub genes and dysregulated pathw

SUBMITTER: Fang K 

PROVIDER: S-EPMC12491135 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature