Expression of FoxP3 in oral squamous cell carcinoma and its biological significance.

ABSTRACT:

Introduction and objective

Oral squamous cell carcinoma (OSCC) is a highly malignant tumor that is prone to lymph node metastasis and distant metastasis. FoxP3 is a specific surface marker of regulatory T cells, and its role in various tumors has been confirmed, which is related to tumor progression and prognosis. However, there are relatively few studies on FoxP3 in OSCC, and the role of FoxP3 in OSCC remains unclear.

Materials and methods

In this study, the expression of FoxP3 in OSCC was analyzed using data from the TCGA public database. Additionally, 78 OSCC patient samples were analyzed using immunohistochemistry to evaluate the role of FoxP3 in the prognosis of OSCC. The data from TCGA were then investigated using GSEA to explore possible carcinogenic mechanisms. Final

SUBMITTER: Jiang L 

PROVIDER: S-EPMC12491139 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature