Comparison of scatter and partial volume correction techniques for quantitative SPECT imaging of ²²⁵Ac.

ABSTRACT:

Background

The extreme low-count regime for clinical ²²⁵Ac-SPECT imaging poses a challenge to energy-window based scatter correction (EWSC) methods. Moreover, SPECT imaging suffers from partial volume effects (PVE), which can degrade quantification and lead to an underestimation of the absorbed dose estimations, especially in small structures such as lesions. The aim of this study was to investigate the impact of scatter correction and partial volume correction (PVC) techniques on post-therapeutic imaging of the three imageable photopeaks of ²²⁵Ac.

Methods

A phantom with three 3D-printed spheres (191, 100, 48 ml) was imaged to compare transmission-dependent scatter correction (TDSC) to EWSC (440, 218 keV)/no scatter correction (no SC) (78 keV), as well

SUBMITTER: Liubchenko G 

PROVIDER: S-EPMC12491142 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature