Iron accumulation in hypothalamus promotes age-dependent obesity and metabolic dysfunction of male mice.

ABSTRACT: With the progression of aging, age-dependent obesity and metabolic disorders have garnered increasing attention, yet their underlying mechanisms remain poorly understood. Dysregulation of iron homeostasis is strongly linked to aging; however, its role in age-dependent obesity remains unclear. As the hypothalamus, a key regulator of energy homeostasis, plays a pivotal role in metabolic regulation during aging, we investigated whether hypothalamic iron accumulation contributes to age-dependent obesity. We first observed elevated iron levels in the hypothalamus of aged mice, particularly in the arcuate nucleus. To test whether reducing iron could mitigate obesity, we intranasally administered the iron chelator deferiprone to aged mice and found that it effectively lowered hypothalamic iron le

SUBMITTER: Wang X 

PROVIDER: S-EPMC12491144 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature