DNA-mediated UCP1 overexpression in adipose tissue: A promising anti-obesity gene therapy.

ABSTRACT:

Background

Obesity has emerged as a global health challenge. Although GLP-1 receptor agonists are showing considerable promise in weight loss, their clinical utility is partly limited by gastrointestinal adverse reactions and non-fat weight loss side effects. UCP1-mediated adipose thermogenesis is a critical process for body temperature maintenance and weight management. However, the lack of effective and specific adipose thermogenesis therapies has restricted its clinical application. We aimed to explore the potential of inducing adipose-specific UCP1 overexpression via modified plasmids as an innovative therapeutic approach for obesity.

Methods

We replaced the cytomegalovirus (CMV) promoter in the plasmids with two types of adipose-specific promoters: mouse adiponectin (mA

SUBMITTER: Zhao ZW 

PROVIDER: S-EPMC12491148 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature