Enhancing the sensitivity of gamma-aminobutyric acid and glutamate biosensors by electrochemically roughening platinum microelectrodes.

ABSTRACT: Gamma-aminobutyric acid (GABA) and glutamate (GLU) are two key neurotransmitters (NTs) in processing, plasticity, memory, and network functions. High-sensitivity GABA and GLU biosensors are crucial for investigating the dysregulation of the GABA-GLU balance and improving animal models and human therapies for multiple neurological disorders. We have developed a novel biosensor that utilizes electrochemically roughened (ECR) platinum (Pt) microelectrodes to achieve the highest sensitivity in detecting hydrogen peroxide (H₂O₂), which serves as the detection signal for the biosensors. We evaluated three microelectrode surface activation techniques-alcohol cleaning, electrochemical cleaning, and ECR-and the main effects of the ECR pulses at varying frequencies (150-6,000 H

SUBMITTER: Adediji MY 

PROVIDER: S-EPMC12491176 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature