Dysregulated NK cell activation and myeloid-lymphoid imbalance underpin COPD progression: insights from high-dimensional immune profiling and smoking-induced immune remodeling.

ABSTRACT:

Background

Chronic obstructive pulmonary disease (COPD) is a significant global health concern, marked by persistent inflammation and immune dysregulation. Although it is widespread and has substantial clinical implications, the systemic immune mechanisms driving disease progression are not fully understood. Since blood contains a diverse array of immune cells and offers a non-invasive means of assessing immune homeostasis and overall physiological status, investigating immune dysregulation through blood sampling offers considerable value for both basic research and clinical application. This approach can provide novel insights into the pathogenesis of COPD.

Methods

This study employed high-dimensional flow cytometry and RNA sequencing to comprehensively characterize periphe

SUBMITTER: Qiao Q 

PROVIDER: S-EPMC12491182 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature