TDCS peripheral nerve stimulation can enhance passive avoidance learning in rats.

ABSTRACT: Transcranial direct current stimulation (tDCS) is being considered as a treatment for many psychiatric and neurological disorders. Rodent models of tDCS have been used in several behavioral tasks to demonstrate the technique's benefits in improving memory and learning. Recent research suggests that peripheral nerve stimulation in tDCS may be responsible for some of its effects. In this work, we first aimed to repeat a previously reported tDCS effect of improved passive avoidance task (PAT) learning in a minimally restrictive rat model and investigate whether peripheral nerve stimulation contributed to these effects by using two additional stimulation groups in which the electric field in the brain (transcranial-only tDCS) and skin (transcutaneous-only tDCS) were separated. Analysis reveale

SUBMITTER: van Boekholdt L 

PROVIDER: S-EPMC12491212 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature