Single-versus multiple-inhaler triple therapy in patients with COPD in Spain: a retrospective cohort study comparing adherence, persistence, risk of exacerbations and economic outcomes.

ABSTRACT: This retrospective study aimed to compare the clinical and economic outcomes of single-inhaler triple therapy (SITT) versus multiple-inhaler triple therapy (MITT) in a large cohort of COPD patients. Metrics on adherence, prevalence, and incidence of exacerbations in COPD patients treated with SITT or MITT were analyzed using pharmacy claims data integrated with the Spanish public health database. At the 12-month follow-up, patients in the SITT cohort were significantly more adherent (75.22% vs 70.1%; OR = 1.33), more persistent (64.32% vs 52.4%; HR = 1.56) and had a lower incidence of moderate exacerbations (53.53% vs 64.07%; OR = 0.65) than patients in the MITT cohort. The main predictors associated with lack of persistence were being a naïve patient (HR = 0.55) and moderate exacerbations

SUBMITTER: Gonzalez-Gonzalez MA 

PROVIDER: S-EPMC12491219 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature