Quantitative nodal burden as a predictive marker for chemotherapy benefit in postoperative ampullary adenocarcinoma: a multi-institution population-based study.

ABSTRACT:

Background

The effectiveness of adjuvant chemotherapy (ACT) in ampullary adenocarcinoma (AA) patients and under what conditions ACT should be applied are not clearly defined.

Methods

The study encompassed a series of consecutive AA patients who underwent curative surgical resection. These patients were sourced from the National Cancer Center of China, spanning the years 1998 to 2020, as well as from 12 registries within the Western surveillance, epidemiology, and end results program, covering the period from 2004 to 2017. The quantitative nodal burden was evaluated using the log odds of positive lymph nodes (LODDS). The correlation between ACT and overall survival (OS), recurrence-free survival (RFS), and cancer-specific survival (CSS), was meticulously evaluated using Cox p

SUBMITTER: Li Z 

PROVIDER: S-EPMC12491244 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature