Comparative study of the chemical profile, cytotoxic activity, and molecular docking of Serenoa repens extract and a pharmaceutical product.

ABSTRACT: Serenoa repens (Bartram) J.K.Small known as Saw palmetto; its herb is widely used for its therapeutic potentials especially in the treatment of urological disorders such as benign prostatic hyperplasia (BPH) in men. Comparative chemical, biological and in silico docking profiling's of Serenoa repens seeds extract (S1) vs. a particular pharmaceutical product (S2) containing Serenoa repens. LCHR-ESI-MS is used for identification of bioactive constituents. MTT Cytotoxic study using Pc3 and DU-145 prostate cancer cell lines is used to measure the cytotoxicity of S1 and S2. Molecular Dynamic (MD) Simulation studies were conducted on the top-scoring docked compounds using Desmond in the Schrödinger software package. The chemical analysis by LCHR-ESI-MS detected about fifty bioactive constituents

SUBMITTER: Mostafa EM 

PROVIDER: S-EPMC12491398 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature