Pincer-cobalt boosts divergent alkene carbonylation under tandem electro-thermo-catalysis.

ABSTRACT: Catalytic multicomponent carbonylation reactions with high regio- and chemoselectivity represent one of the long-pursued goals in C1 chemistry. We herein disclose a practical cobalt-catalyzed divergent radical alkene carbonylative functionalization under 1 atm of CO at 23 °C. The leverage of the tridentate NNN-type pincer ligand is the key to avoid the formation of catalytically inert Co⁰(CO)_n species and overcome the occurrence of oxidative carbonylation of organozincs, selectively tuning the catalytic reactivity of cobalt center for dictating a full cobalt-catalyzed four-component carbonylation. Moreover, direct use CO₂ as the C1 source in the multicomponent alkene carbonylative couplings can be achieved under a tandem electro-thermo-catalysis, thus allow

SUBMITTER: Ge S 

PROVIDER: S-EPMC12491415 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature